[Diffusion-weighted MRI in patients with Creutzfeldt-Jakob disease]

Nervenarzt. 2000 Feb;71(2):91-5. doi: 10.1007/s001150070001.
[Article in German]


Today the diagnosis of Creutzfeldt-Jakob disease (CJD) is proven only postmortem or by evidence of neuropathology. During the patient's lifetime EEG recordings or cerebrospinal fluid analysis may support the diagnosis. In most cases, T2-MRI scans show hyperintensities of the basal ganglia. A new imaging technique called diffusion-weighted MRI (DWI) has recently been established. The sensitivity of DWI was evaluated in five patients suspected of CJD. All five cases showed hyperintense signal changes in the basal ganglia on DWI sequences. These findings were more pronounced in DWI than in T2, FLAIR, or PD-weighted images. Thus, DWI seems to be the most sensitive sequence for detecting changes in patients with suspected CJD. Moreover, its short scanning time ensures that fewer artifacts occur, especially in the case of myoclonus.

Publication types

  • Case Reports
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Artifacts
  • Basal Ganglia / pathology
  • Basal Ganglia Diseases / diagnosis*
  • Basal Ganglia Diseases / pathology
  • Creutzfeldt-Jakob Syndrome / diagnosis*
  • Creutzfeldt-Jakob Syndrome / pathology
  • Diagnosis, Differential
  • Diffusion
  • Female
  • Humans
  • Image Enhancement*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged