Interactions of HIV-1 NEF with cellular signal transducing proteins

Front Biosci. 2000 Feb 1;5:D268-83. doi: 10.2741/renkema.


Nef is a 27 - 34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques (1). In a transgenic mouse model expression of Nef protein alone when expressed under a CD4-promoter is sufficient to cause an AIDS like disease (2). A critical role for Nef in development of AIDS in humans is suggested by the observation that some individuals with a long-term nonprogressive HIV-1 infection are infected with viruses carrying naturally occurring Nef deletions (3-5). The mechanism of Nef action remains incompletely understood, but multiple lines of evidence point out to a role in modulation of cellular signaling pathways via physical and functional interactions with host cell proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CD4 Antigens / genetics
  • CD4 Antigens / metabolism
  • Gene Products, nef / metabolism*
  • HIV-1 / metabolism*
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Mice
  • Molecular Sequence Data
  • Protein-Serine-Threonine Kinases / metabolism
  • Proteins / metabolism*
  • Receptors, Antigen, T-Cell / metabolism
  • Signal Transduction*
  • nef Gene Products, Human Immunodeficiency Virus
  • src Homology Domains


  • CD4 Antigens
  • Gene Products, nef
  • Histocompatibility Antigens Class I
  • Proteins
  • Receptors, Antigen, T-Cell
  • nef Gene Products, Human Immunodeficiency Virus
  • Protein-Serine-Threonine Kinases