Planar polarity: out of joint?

Curr Biol. 2000 Feb 24;10(4):R155-8. doi: 10.1016/s0960-9822(00)00330-4.

Abstract

Epithelial structures, such as the wing hairs and ommatidia in Drosophila, are aligned in the plane of the epithelium. This planar polarity requires the transmembrane receptor Frizzled. Recent studies have shed new light on mechanisms that could be involved in generating or transducing the polarity signal.

Publication types

  • Review

MeSH terms

  • Animals
  • Cadherins / genetics
  • Cadherins / physiology*
  • Cell Polarity / physiology*
  • Drosophila Proteins*
  • Frizzled Receptors
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, G-Protein-Coupled
  • Signal Transduction

Substances

  • CELSR2 protein, human
  • Cadherins
  • Drosophila Proteins
  • Frizzled Receptors
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • fj protein, Drosophila
  • fz protein, Drosophila