Frequency doubling technology perimetry for detection of glaucomatous visual field loss

Am J Ophthalmol. 2000 Mar;129(3):314-22. doi: 10.1016/s0002-9394(99)00414-6.


Purpose: To evaluate the ability of frequency doubling technology perimetry to detect early, moderate, and advanced glaucomatous visual field loss.

Methods: In a prospective study, frequency doubling technology perimetry (C-20 full threshold) was performed in the right eye of 254 normal control subjects and 230 patients with early (n = 85), moderate (n = 114), or advanced (n = 31) glaucomatous visual field loss. Previous Humphrey Field Analyzer test results were used to classify glaucomatous visual field loss as early (mean deviation no worse than -6 dB), moderate (mean deviation between -6 and -12 dB) or advanced (mean deviation between -12 and -22 dB).

Results: Receiver operating characteristic curves showed 100% sensitivity and specificity (area under the curve, 1.0) for detecting advanced glaucomatous visual field loss, approximately 96% sensitivity and 96% specificity (area under the curve, 0.9751) for detecting moderate glaucomatous visual field loss, and approximately 85% sensitivity and 90% specificity (area under the curve, 0.9261) for early glaucomatous visual field loss.

Conclusions: Frequency doubling technology perimetry demonstrates high sensitivity and specificity for detection of early, moderate, and advanced glaucomatous visual field loss.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • False Positive Reactions
  • Glaucoma / diagnosis*
  • Humans
  • Intraocular Pressure
  • Middle Aged
  • Optic Nerve Diseases / diagnosis*
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Vision Disorders / diagnosis*
  • Visual Field Tests / methods*
  • Visual Fields*