High prevalence of herpes simplex virus type 2 in acute retinal necrosis syndrome associated with herpes simplex virus in Japan

Am J Ophthalmol. 2000 Mar;129(3):404-5. doi: 10.1016/s0002-9394(99)00391-8.

Abstract

Purpose: To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus.

Methods: Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular specimens from 16 patients with acute retinal necrosis syndrome. Anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 type-specific antibodies in serum from the patients were detected by enzyme immunoassay.

Results: Of 16 patients with acute retinal necrosis syndrome, seven were polymerase chain reaction positive for herpes simplex virus type 2 and nine were positive for varicella-zoster virus. Anti-herpes simplex virus type 2 antibody was positive and anti-herpes simplex virus type 1 antibody was negative in the sera of the seven patients with herpes simplex virus type 2 DNA-positive acute retinal necrosis syndrome. In contrast, anti-herpes simplex virus type 2 antibody was absent in all nine varicella-zoster virus DNA-positive acute retinal necrosis syndrome patients.

Conclusion: Herpes simplex virus type 2 has been demonstrated to be the major causative agent in acute retinal necrosis syndrome associated with herpes simplex virus by molecular biological and serological methods. Negative preexisting anti-herpes simplex virus type 1 antibody may play an important role in acute retinal necrosis syndrome associated with herpes simplex virus type 2.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / analysis
  • Aqueous Humor / virology
  • Cytomegalovirus / genetics
  • Cytomegalovirus / immunology
  • Cytomegalovirus / isolation & purification
  • DNA, Viral / analysis
  • Enzyme-Linked Immunosorbent Assay
  • Eye Infections, Viral / epidemiology
  • Eye Infections, Viral / virology*
  • Female
  • Herpes Genitalis / epidemiology
  • Herpes Genitalis / virology*
  • Herpesvirus 1, Human / genetics
  • Herpesvirus 1, Human / immunology
  • Herpesvirus 1, Human / isolation & purification
  • Herpesvirus 2, Human / genetics
  • Herpesvirus 2, Human / isolation & purification*
  • Herpesvirus 3, Human / genetics
  • Herpesvirus 3, Human / immunology
  • Herpesvirus 3, Human / isolation & purification
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / immunology
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Prevalence
  • Retinal Necrosis Syndrome, Acute / epidemiology
  • Retinal Necrosis Syndrome, Acute / virology*
  • Vitreous Body / virology

Substances

  • Antibodies, Viral
  • DNA, Viral