Interleukin-18: biological properties and clinical implications

Eur Cytokine Netw. 2000 Mar;11(1):15-26.


IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Communicable Diseases / immunology
  • Cytokines / biosynthesis
  • Cytokines / genetics
  • Cytotoxicity, Immunologic
  • Humans
  • Immunity, Cellular
  • Inflammation / immunology
  • Interleukin-18 / physiology*
  • Interleukin-18 Receptor alpha Subunit
  • Neoplasms / immunology
  • Receptors, Interleukin / physiology
  • Receptors, Interleukin-18


  • Cytokines
  • IL18R1 protein, human
  • Interleukin-18
  • Interleukin-18 Receptor alpha Subunit
  • Receptors, Interleukin
  • Receptors, Interleukin-18