Lymphatic transport of proteins after subcutaneous administration

J Pharm Sci. 2000 Mar;89(3):297-310. doi: 10.1002/(SICI)1520-6017(200003)89:3<297::AID-JPS2>3.0.CO;2-P.


This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration. A review of the physiology of the lymphatics and inherent anatomical differences between blood and lymph capillaries is presented followed by a brief overview of the general characteristics of protein absorption and bioavailability following S.C. injection. A description of factors known to directly affect the lymphatic uptake of macromolecules follows and is supported by representative data from this laboratory. A brief perspective on the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics is presented.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Humans
  • Injections, Subcutaneous
  • Lymphatic System / metabolism*
  • Proteins / administration & dosage
  • Proteins / metabolism*
  • Proteins / pharmacokinetics


  • Proteins