Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction

Acta Cardiol. 2000 Feb;55(1):9-15. doi: 10.2143/AC.55.1.2005712.


We studied the effects of glucose, insulin, and KCl infusion (GIK), on regional myocardial perfusion and function by 99m-Tc-tetrofosmin-gated SPECT.

Methods: We studied 21 male patients with their first uncomplicated acute myocardial infarction (AMI). All patients underwent a rest and submaximal stress before and after 24-hour infusion of GIK-solution (group A) or saline solution (group B).

Results: Group A showed better stress tolerance and ischaemic threshold improvement after GIK infusion whilst no statistical differences were found between basal and post-infusion test in group B. At first the stress test in group A, of the 192 segments analysed, 52 (27%) showed reversible perfusion defect. In group B, of 144 segments analysed, 31 (21%) showed reversible perfusion defect. A post-infusion analysis in group A showed a post-GIK end-diastolic significant count improvement in 21 segments, and a post-GIK end-systolic count improvement in 22 segments. In group B, perfusion increase was observed only in 4 segments, whilst systolic thickening increase was observed only in 1 segment.

Conclusion: These data demonstrate the efficacy of GIK infusion to improve regional myocardial perfusion and function mainly in segments adjacent to the recently infarcted area.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Cardioplegic Solutions / administration & dosage*
  • Chi-Square Distribution
  • Coronary Angiography / statistics & numerical data
  • Double-Blind Method
  • Electrocardiography
  • Exercise Test / methods
  • Exercise Test / statistics & numerical data
  • Glucose / administration & dosage
  • Heart / drug effects*
  • Heart / physiopathology
  • Humans
  • Insulin / administration & dosage
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / physiopathology
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Potassium / administration & dosage
  • Radiopharmaceuticals
  • Tomography, Emission-Computed, Single-Photon / methods
  • Tomography, Emission-Computed, Single-Photon / statistics & numerical data


  • Cardioplegic Solutions
  • Insulin
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • glucose-insulin-potassium cardioplegic solution
  • technetium tc-99m tetrofosmin
  • Glucose
  • Potassium