Abstract
Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Arousal / drug effects
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Circadian Rhythm / drug effects
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Depressive Disorder, Major / diagnosis
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Depressive Disorder, Major / drug therapy
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Depressive Disorder, Major / psychology
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Administration Schedule
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Female
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Humans
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Male
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Melatonin / administration & dosage*
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Melatonin / adverse effects
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Middle Aged
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Personality Assessment
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Personality Inventory
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Seasonal Affective Disorder / diagnosis
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Seasonal Affective Disorder / drug therapy*
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Seasonal Affective Disorder / psychology