Keratomycosis: clinical and microbiologic experience with dematiaceous fungi

Ophthalmology. 2000 Mar;107(3):574-80. doi: 10.1016/s0161-6420(99)00079-2.


Objective: To assess the significance of dematiaceous fungi in the causation of keratomycosis.

Design: Retrospective, noncomparative case series.

Participants: Eighty-eight cases of dematiaceous fungal keratitis seen at the L. V. Prasad Eye Institute, Hyderabad, India from January 1991 through December 1996.

Intervention: Only culture-proven cases were analyzed.

Main outcome measures: Predisposing factors, clinical characteristics, microbiology, treatment methods, and outcome.

Results: Of 557 cases of fungal keratitis seen during the study period, dematiaceous fungi were the etiologic agents in 88 (15.7%), after Fusarium in 210 (37.6%) and Aspergillus species in 170 cases (30.4%), respectively. Trauma was the most common predisposing factor (47.7%). Fifty-three eyes (61.3%) had the classical clinical picture of yellow-white, dry raised infiltrate with feathery hyphate edges at initial examination. The characteristic macroscopic pigmentation was seen in only 24 eyes (27.27%). Septate branching fungal filaments were identified in 78 smears (88.63%) on light microscopy, of which 5 (5.7%) also showed the presence of bacteria. Curvularia species dominated the spectrum (22.7%). Treatment was started in 48 eyes with topical antifungal agents, whereas 37 received both oral and topical antifungal agents. Outcome data were available for 68 cases. Forty-nine (72%) responded to medical therapy, whereas 13 eyes required therapeutic penetrating keratoplasty and 6 eyes had to be eviscerated.

Conclusions: This is the largest series of keratitis caused by dematiaceous fungi reported to date. It clearly brings out the clinical importance of this group of corneal infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Child
  • Child, Preschool
  • Cornea / microbiology*
  • Cornea / pathology
  • Eye Infections, Fungal* / diagnosis
  • Eye Infections, Fungal* / drug therapy
  • Eye Infections, Fungal* / microbiology
  • Female
  • Humans
  • Infant
  • Keratitis / diagnosis
  • Keratitis / drug therapy
  • Keratitis / microbiology*
  • Male
  • Middle Aged
  • Mitosporic Fungi / isolation & purification*
  • Mycoses* / diagnosis
  • Mycoses* / drug therapy
  • Mycoses* / microbiology
  • Retrospective Studies


  • Antifungal Agents