Pulse-inversion mode imaging of liver specific microbubbles: improved detection of subcentimetre metastases

Lancet. 2000 Mar 4;355(9206):807-8. doi: 10.1016/S0140-6736(99)04545-6.


Pulse-inversion mode (a new ultrasound mode) can be used to image the late liver-specific parenchymal phase of the microbubble contrast-agent Levovist. Scanning in pulse-inversion mode after Levovist improves the detection of liver metastases and reveals more lesions of smaller size than conventional ultrasonography and computed tomography.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / diagnostic imaging*
  • Contrast Media*
  • Humans
  • Image Enhancement*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / secondary*
  • Polysaccharides*
  • Sensitivity and Specificity
  • Ultrasonography


  • Contrast Media
  • Polysaccharides
  • SHU 508