Does the migraine aura reflect cortical organization?

Eur J Neurosci. 2000 Feb;12(2):767-70. doi: 10.1046/j.1460-9568.2000.00995.x.

Abstract

Individuals suffering from classical migraine report an astonishing diversity of migraine auras. A frequently reported symptom is a visual hallucination known as fortification illusion (FI). Here we demonstrate that the typical zig-zag pattern of the FI can be reproduced using experimental data of orientation maps of the primary visual cortex (V1) assuming that a continuous excitation front propagates across V1. We put forward a model in which the cortical neurons within this excitation wave are activated sufficiently to contribute to conscious perception. It is shown that the discontinuous repetitive nature of the zig-zag pattern of the FI can reflect the specific layout of visual cortical orientation maps. Additionally, dynamic features of the FI are predicted based on our model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Cats
  • Cortical Spreading Depression / physiology*
  • Electrophysiology
  • Epilepsy / physiopathology
  • Humans
  • Migraine with Aura / physiopathology*
  • Models, Neurological
  • Scotoma / physiopathology*
  • Visual Cortex / physiology*