Neurotrophins: neurotrophic modulation of neurite growth

Curr Biol. 2000 Mar 9;10(5):R198-200. doi: 10.1016/s0960-9822(00)00351-1.


As well as regulating neuronal survival, neurotrophins control the growth of axons and dendrites. New light has been shed on the mechanism of this latter control process by the discovery that the common neurotrophin receptor p75(NTR) interacts in a ligand-dependent manner with RhoA, a known regulator of actin assembly.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division
  • Gene Library
  • Glycoproteins / metabolism
  • Mice
  • Nerve Growth Factors / physiology*
  • Neurites / physiology*
  • Protein-Tyrosine Kinases / metabolism
  • Receptor, Nerve Growth Factor / metabolism*
  • Receptor, Nerve Growth Factor / physiology*
  • Receptor, trkA / metabolism


  • Glycoproteins
  • Nerve Growth Factors
  • Receptor, Nerve Growth Factor
  • Protein-Tyrosine Kinases
  • Receptor, trkA