Protein kinases: six degrees of separation?

Curr Biol. 2000 Mar 9;10(5):R191-4. doi: 10.1016/s0960-9822(00)00349-3.


Recent evidence for cross-talk between protein kinase B (PKB) and the Raf-1 and NF-kappaB signalling pathways has provided new hints to the complex roles that PKB may play in regulating gene transcription and also raised questions about where and when these targets are relevant.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Line
  • Cell Survival
  • Gene Expression Regulation, Enzymologic*
  • Humans
  • Ligands
  • Models, Biological
  • NF-kappa B / metabolism*
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-raf / metabolism*
  • Signal Transduction*
  • Transcription, Genetic


  • Ligands
  • NF-kappa B
  • Proto-Oncogene Proteins
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-raf