Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Curr Opin Cell Biol. 2000 Apr;12(2):174-9. doi: 10.1016/s0955-0674(99)00073-3.


The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered and characterized. In addition, several new highly specific PDE inhibitors have been developed and approved for clinical use. Finally, new strategies have been employed to determine PDE function in model systems including the use of antisense oligonucleotide and disruption techniques.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / metabolism
  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic GMP / metabolism*
  • Fertility / physiology
  • Insulin / metabolism
  • Insulin Secretion
  • Lymphocyte Activation
  • Male
  • Penile Erection / physiology
  • Phosphoric Diester Hydrolases / metabolism*
  • Signal Transduction*
  • T-Lymphocytes / immunology


  • Insulin
  • Cyclic AMP
  • PDE10A protein, human
  • Phosphoric Diester Hydrolases
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic GMP