A-kinase anchoring proteins: protein kinase A and beyond

Curr Opin Cell Biol. 2000 Apr;12(2):217-21. doi: 10.1016/s0955-0674(99)00085-x.


Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Caenorhabditis elegans Proteins*
  • Carrier Proteins / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Cytoskeletal Proteins*
  • Drosophila Proteins*
  • Membrane Proteins / metabolism*
  • Proteins / metabolism
  • Seminal Plasma Proteins*


  • A Kinase Anchor Proteins
  • A kinase anchor protein (kap-1), C elegans
  • AKAP2 protein, human
  • AKAP5 protein, human
  • AKAP7 protein, human
  • AKAP9 protein, human
  • Adaptor Proteins, Signal Transducing
  • Akap200 protein, Drosophila
  • Akap7 protein, mouse
  • Caenorhabditis elegans Proteins
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Drosophila Proteins
  • Membrane Proteins
  • Proteins
  • Seminal Plasma Proteins
  • Cyclic AMP-Dependent Protein Kinases