The Ras branch of small GTPases: Ras family members don't fall far from the tree

Curr Opin Cell Biol. 2000 Apr;12(2):157-65. doi: 10.1016/s0955-0674(99)00071-x.


The Ras branch of the Ras superfamily consists of small GTPases most closely related to Ras and include the R-Ras, Rap, Ral, Rheb, Rin and Rit proteins. Although our understanding of Ras signaling and biology is now considerable, recent observations suggest that Ras function is more complex than previously believed. First, the three Ras proteins may not be functionally identical. Second, Ras function involves functional cross-talk with their close relatives.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • GTP Phosphohydrolases / metabolism*
  • Humans
  • Signal Transduction*
  • ras Proteins / metabolism
  • ras Proteins / physiology*


  • GTP Phosphohydrolases
  • RIT1 protein, human
  • Rin protein (GTPase)
  • ras Proteins