Smads as transcriptional co-modulators

Curr Opin Cell Biol. 2000 Apr;12(2):235-43. doi: 10.1016/s0955-0674(99)00081-2.


The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • Cell Nucleus / physiology
  • DNA-Binding Proteins / metabolism*
  • Drosophila
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Serine Endopeptidases*
  • Signal Transduction*
  • Smad4 Protein
  • Trans-Activators / metabolism*
  • Transcription, Genetic*
  • Transforming Growth Factor beta / metabolism*
  • Ubiquitins / metabolism


  • Carrier Proteins
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • SMAD4 protein, human
  • Smad4 Protein
  • Trans-Activators
  • Transforming Growth Factor beta
  • Ubiquitins
  • ZFYVE16 protein, human
  • Serine Endopeptidases