Notch signaling in T cell development

Curr Opin Immunol. 2000 Apr;12(2):166-72. doi: 10.1016/s0952-7915(99)00067-9.

Abstract

Notch signaling regulates cell fate decisions during development. Recent experiments suggest that Notch signaling is essential for initial commitment to the T cell lineage and may function together with signals from the pre-TCR and the TCR to regulate subsequent steps of T cell development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / cytology
  • Cell Differentiation
  • Cell Lineage
  • Feedback
  • Gene Expression Regulation, Developmental*
  • Hematopoiesis* / genetics
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Receptor, Notch1
  • Receptor, Notch2
  • Receptor, Notch4
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, Notch
  • Signal Transduction
  • T-Lymphocyte Subsets / cytology*
  • Thymus Gland / cytology
  • Transcription Factors / classification
  • Transcription Factors / physiology
  • Transcription, Genetic

Substances

  • Membrane Proteins
  • NOTCH1 protein, human
  • NOTCH2 protein, human
  • NOTCH4 protein, human
  • Notch1 protein, mouse
  • Notch2 protein, mouse
  • Proto-Oncogene Proteins
  • Receptor, Notch1
  • Receptor, Notch2
  • Receptor, Notch4
  • Receptors, Antigen, T-Cell
  • Receptors, Cell Surface
  • Receptors, Notch
  • Transcription Factors
  • Notch4 protein, mouse