[The general characteristics and short- and long-term results of infective endocarditis in non-drug addicts]

Rev Esp Cardiol. 2000 Mar;53(3):344-52. doi: 10.1016/s0300-8932(00)75102-5.
[Article in Spanish]


Introduction and objectives: Infective endocarditis is a disease with a high morbimortality during the active phase and a considerable risk of complications during follow-up. The aim of our study is to describe the clinical and prognostic features of infective endocarditis in non-drug addict patients in short and long terms.

Patients and methods: A prospective study of 138 cases of infective endocarditis in non-drug addict patients through the parenteral pathway treated in our institution from 1987 to 1997.

Results: The mean age was 44 +/- 20 years. Ninety-five patients (69%) had native valve infective endocarditis and forty-three (31%) had prosthetic valve endocarditis. Streptococci were the causal microorganism in 34% and staphylococci in 33%. 83% of patients developed some type of complications during hospital stay. 51% of patients were operated on during the active phase (22% were urgent). The in-hospital mortality rate was 21%. 10 patients (9%) needed late cardiac surgery and seven patients (5%) died during follow-up. Global survival at 10 years was 71%. There were no statistical differences in survival in as much as the type of treatment received during the hospital stay in the active phase (medical alone or combined medical-surgical).

Conclusions: A high early surgery rate in the active phase related to good long-term results and does not increase early in-hospital mortality. Medical treatment also offers good long-term results in cases of infectious endocarditis with absence of bad prognostic factors and good clinical outcome.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / diagnosis*
  • Endocarditis, Bacterial / mortality
  • Endocarditis, Bacterial / therapy
  • Female
  • Follow-Up Studies
  • Heart Valve Prosthesis / adverse effects
  • Hospital Mortality
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Prosthesis-Related Infections / complications
  • Prosthesis-Related Infections / diagnosis
  • Prosthesis-Related Infections / mortality
  • Prosthesis-Related Infections / therapy
  • Spain / epidemiology
  • Substance Abuse, Intravenous
  • Time Factors