Abstract
An antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody reacted to not only AMPD-4, but also FTY720, it should be useful for immunoassay of FTY720 in body fluids, tissues and cells.
MeSH terms
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Animals
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Antibodies / immunology*
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Antibody Formation
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Antibody Specificity
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Cross Reactions
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Enzyme-Linked Immunosorbent Assay
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Fatty Acids, Monounsaturated / chemical synthesis
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Fatty Acids, Monounsaturated / chemistry
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Fatty Acids, Monounsaturated / immunology*
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Fingolimod Hydrochloride
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Immunosuppressive Agents / chemical synthesis
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / immunology*
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Propanolamines / chemical synthesis
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Propanolamines / chemistry
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Propanolamines / immunology*
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Propylene Glycols / chemical synthesis
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Propylene Glycols / chemistry
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Propylene Glycols / immunology*
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Rabbits
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Sphingosine / analogs & derivatives
Substances
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AMPD 4
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Antibodies
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Fatty Acids, Monounsaturated
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Immunosuppressive Agents
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Propanolamines
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Propylene Glycols
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Fingolimod Hydrochloride
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Sphingosine
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thermozymocidin