Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome

Acta Obstet Gynecol Scand. 2000 Mar;79(3):180-8.

Abstract

Background: The present study was designed to evaluate if electro-acupuncture (EA) could affect oligo-/anovulation and related endocrine and neuroendocrine parameters in women with polycystic ovary syndrome (PCOS).

Methods: Twenty-four women (between the ages of 24 and 40 years) with PCOS and oligo-/amenorrhea were included in this non-randomized, longitudinal, prospective study. The study period was defined as the period extending from 3 months before the first EA treatment, to 3 months after the last EA treatment (10-14 treatments), in total 8-9 months. The menstrual and ovulation patterns were confirmed by recording of vaginal bleedings and by daily registrations of the basal body temperature (BBT). Blood samples were collected within a week before the first EA, within a week after the last EA and 3 months after EA.

Results: Nine women (38%) experienced a good effect. They displayed a mean of 0.66 ovulations/woman and month in the period during and after the EA period compared to a mean of 0.15 before the EA period (p=0.004). Before EA, women with a good effect had a significantly lower body-mass index (BMI) (p<0.001), waist-to-hip circumference ratio (WHR) (p=0.0058), serum testosterone concentration (p=0.0098), serum testosterone/sex hormone binding globulin (SHBG) ratio (p=0.011) and serum basal insulin concentration (p=0.0054), and a significantly higher concentration of serum SHBG (p=0.040) than did those women with no effect.

Conclusion: Repeated EA treatments induce regular ovulations in more than one third of the women with PCOS. The group of women with good effect had a less androgenic hormonal profile before treatment and a less pronounced metabolic disturbance compared with the group with no effect. For this selected group EA offers an alternative to pharmacological ovulation induction.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Androgens / blood
  • Anovulation / blood
  • Anovulation / therapy*
  • Body Constitution
  • Body Mass Index
  • Electroacupuncture*
  • Female
  • Gonadotropins / blood
  • Humans
  • Longitudinal Studies
  • Ovulation Induction*
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / therapy*
  • Prolactin / blood
  • Prospective Studies
  • Sex Hormone-Binding Globulin / metabolism
  • beta-Endorphin / blood

Substances

  • Androgens
  • Gonadotropins
  • Sex Hormone-Binding Globulin
  • beta-Endorphin
  • Prolactin