Expression of hnRNP A2/B1 proteins in human cancer cell lines

Int J Oncol. 2000 Apr;16(4):763-7. doi: 10.3892/ijo.16.4.763.


The overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is recently reported informative as a marker of lung cancer for early detection. To examine whether the expression of the proteins is specific for lung cancer, immunological analyses were performed both in lung and non-lung cancer cell lines. In immunostaining and Western blotting, the expression of A2/B1 was observed not only in the lung cancer cells but also in non-lung cancer cells. The expression of hnRNP A2/B1 is not specific for lung cancer and quantitative determination of A2/B1 is required to elucidate their significance in carcinogenesis.

MeSH terms

  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B*
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Immunoblotting
  • Lung Neoplasms / chemistry
  • Microscopy, Fluorescence
  • Neoplasms / chemistry*
  • Ribonucleoproteins / analysis*
  • Tumor Cells, Cultured


  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Ribonucleoproteins
  • hnRNP A2