Persistent hiccup as presenting symptom in medulla oblongata cavernoma: a case report and review of the literature

Clin Neurol Neurosurg. 2000 Mar;102(1):13-7. doi: 10.1016/s0303-8467(99)00058-x.


A rare case of persistent intractable hiccup as presenting symptom of cavernous angioma in the medulla oblongata is reported. Pathophysiologic hypotheses about the triggering mechanism of hiccup are discussed, with special reference to the causes affecting the central nervous system. A review of the literature concerning medullary lesions presenting with persistent hiccup is also reported. Finally we have included some brief considerations about cavernous angiomas and the patterns of their clinical presentation, focusing on those located in the medulla oblongata.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / complications*
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Hemangioma, Cavernous / complications*
  • Hemangioma, Cavernous / pathology*
  • Hemangioma, Cavernous / surgery
  • Hiccup / diagnosis
  • Hiccup / etiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Medulla Oblongata / pathology*
  • Medulla Oblongata / surgery
  • Middle Aged