Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

Gene. 2000 Mar 21;245(2):223-35. doi: 10.1016/s0378-1119(00)00014-7.


Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Cell Differentiation
  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation, Neoplastic
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Leukemia, Myeloid / genetics*
  • Leukemia, Myeloid / physiopathology
  • Proto-Oncogene Proteins*
  • Transcription Factors / genetics*
  • Transcription Factors / physiology
  • Translocation, Genetic


  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • RUNX1 protein, human
  • Transcription Factors