Effects of lamotrigine on behavioral and cardiovascular responses to cocaine in human subjects

Am J Drug Alcohol Abuse. 2000 Feb;26(1):47-59. doi: 10.1081/ada-100100590.


We evaluated the effects of acute pretreatment with lamotrigine, a putative glutamate release inhibitor, on the physiological and behavioral responses to intranasal cocaine in cocaine-dependent volunteers (N = 8). The study employed a double-blind, placebo-controlled, within-subject design. Subjects participated in six experimental sessions. On each study day, placebo, lamotrigine 125 mg, or lamotrigine 250 mg was administered orally in the morning, followed 2 hours later by intranasal cocaine 120 mg/70 kg or placebo. Measurements of heart rate and blood pressure were acquired, and subjects responded to mood state questionnaires at predetermined time intervals. Cocaine alone produced increases in heart rate, blood pressure, and several measures of pleasurable mood and drug effects. Lamotrigine alone produced a mild relaxing effect. Lamotrigine pretreatment altered neither the physiological responses nor the subjective ratings of cocaine's pleasurable or aversive mood effects.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adult
  • Affect / drug effects*
  • Arousal / drug effects*
  • Blood Pressure / drug effects*
  • Cocaine-Related Disorders / psychology*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Female
  • Heart Rate / drug effects*
  • Humans
  • Lamotrigine
  • Male
  • Premedication
  • Triazines / pharmacology*


  • Excitatory Amino Acid Antagonists
  • Triazines
  • Lamotrigine