N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning

Behav Neurosci. 2000 Feb;114(1):84-98. doi: 10.1037//0735-7044.114.1.84.


The effect of microinfusion of the N-methyl-D-aspartate (NMDA) antagonist 2-amino-5-phosphonopentanoic acid (AP-5) into the amygdala, medial prefrontal cortex, and dorsal and ventral subiculum on acquisition of a lever-pressing task for food in rats was examined. Serial transmission between the basolateral amygdala and nucleus accumbens core was also examined in an asymmetric infusion design. AP-5 administered bilaterally into either the amygdala or medial prefrontal cortex markedly impaired learning, whereas administration into the dorsal or ventral subiculum had no effect. Unilateral infusion of AP-5 into either the nucleus accumbens core or amygdala was also sufficient to impair learning. These data provide novel evidence for NMDA receptor-dependent plasticity within corticostriatal networks in the acquisition of appetitive instrumental learning.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / physiology
  • Animals
  • Appetitive Behavior / physiology*
  • Brain Mapping
  • Cerebral Cortex / physiology*
  • Conditioning, Operant / physiology*
  • Corpus Striatum / physiology*
  • Hippocampus / physiology
  • Male
  • Nerve Net / physiology*
  • Neuronal Plasticity / physiology*
  • Prefrontal Cortex / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / physiology*


  • Receptors, N-Methyl-D-Aspartate