Hepatocyte growth factor/scatter factor-induced intracellular signalling

Int J Exp Pathol. 2000 Feb;81(1):17-30. doi: 10.1046/j.1365-2613.2000.00138.x.

Abstract

Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c-met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hepatocyte Growth Factor / genetics*
  • Hepatocyte Growth Factor / physiology
  • Humans
  • Liver / cytology
  • Liver / metabolism*
  • Phenotype
  • Proto-Oncogene Proteins c-met / physiology*
  • Signal Transduction / physiology*

Substances

  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met