Schizophrenia: the fundamental questions

Brain Res Brain Res Rev. 2000 Mar;31(2-3):106-12. doi: 10.1016/s0165-0173(99)00027-2.


Identifying the correct phentotype of schizophrenia is perhaps the most important goal of modern research in schizophrenia. This identification is the necessary antecedent of indentifying the pathophysiology and etiology. A working model is proposed, which suggests that the phenotype should be defined on the basis of abnormalities in neural circuits and a fundamental cognitive process. This type of unitary model may be more heuristic than early ones that were based on heterogeneous signs and symptoms.

Publication types

  • Review

MeSH terms

  • Humans
  • Schizophrenia* / epidemiology
  • Schizophrenia* / etiology
  • Schizophrenia* / physiopathology