Glutathione S-transferase: genetics and role in toxicology

Toxicol Lett. 2000 Mar 15;112-113:357-63. doi: 10.1016/s0378-4274(99)00230-1.

Abstract

The glutathione S-transferases (GST) are a supergene family of dimeric, enzymes that catalyse the conjugation of glutathione (GSH) to a variety of electrophiles including arene oxides, unsaturated carbonyls, organic halides and other substrates. Their importance is suggested by the finding that GST enzymes are expressed in probably all life forms. In humans, polymorphism in GST genes has been associated with susceptibility to various diseases though some recent data indicate that these genotypes modify disease phenotype. Thus, GST genotypes alone and in combination have been linked with clinical outcome.

Publication types

  • Review

MeSH terms

  • Carcinoma, Basal Cell / genetics
  • Female
  • Genetic Predisposition to Disease
  • Glutathione Transferase / genetics*
  • Glutathione Transferase / physiology
  • Humans
  • Ovarian Neoplasms / genetics
  • Polymorphism, Genetic
  • Skin Neoplasms / genetics
  • Toxicology

Substances

  • Glutathione Transferase