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, 14 (2), 137-42

CTX-M-type Beta-Lactamases: An Emerging Group of Extended-Spectrum Enzymes

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CTX-M-type Beta-Lactamases: An Emerging Group of Extended-Spectrum Enzymes

L S Tzouvelekis et al. Int J Antimicrob Agents.

Abstract

CTX-M-type beta-lactamases constitute a novel group of class A beta-lactamases with extended-spectrum properties. They are encoded by transferable plasmids and found in various enterobacteria, mostly Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. CTX-M enzymes share extensive sequence similarity with the chromosomal beta-lactamases of Klebsiella oxytoca. They efficiently hydrolyze many newer broad-spectrum oximino-beta-lactams including cefotaxime, ceftriaxone and aztreonam and are readily inhibited by tazobactam and clavulanate. CTX-M-producing enterobacteria are endemic in Latin America and in some areas of North Eastern Europe. Data on their structure, properties and epidemiology are discussed.

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