Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma

Dig Surg. 2000;17(1):42-8. doi: 10.1159/000018799.


Background: In patients with hepatocellular carcinoma (HCC), tumor recurrence is not infrequent after resection. It is presumed that characteristics of the tumor such as cellular malignancy might influence the prognosis of the patients in association with tumor stage and radicality of the procedure.

Methods: Univariate and multivariate analyses were used to retrospectively determine the clinicopathologic factors potentially related to survival in 40 patients who underwent hepatectomy for HCC.

Results: In univariate analysis, tumor stage I or II, mitotic index of 4 or less/10 random high-power fields, solitary tumor, and curative resection were significantly correlated with better survival. In multivariate analysis, the mitotic index and surgical curability were independently significant variables influencing survival of patients, and the mitotic index was the best predictive factor. A highly significant correlation was found between the mitotic index and Ki-67 labeling index. Compared to tumors with a mitotic index of 4 or less, those with a mitotic index of 5 or more had a higher association with multiple tumors and advanced tumor stage, which preclude curative resection.

Conclusion: Analysis of the mitotic index is quite simple, and the mitotic index could be a useful factor for predicting the long-term survival of patients with HCC following hepatic resection.

MeSH terms

  • Carcinoma, Hepatocellular / mortality*
  • Carcinoma, Hepatocellular / surgery*
  • Hepatectomy
  • Humans
  • Ki-67 Antigen / analysis
  • Liver Neoplasms / mortality*
  • Liver Neoplasms / surgery*
  • Mitotic Index
  • Multivariate Analysis
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Survival Rate
  • Time Factors


  • Ki-67 Antigen