At the moment, it could be possible to integrate scientific, conventional and unconventional and alternative medicine to improve the efficacy and the quality of therapies. This could be feasible thanks to the following details: a) after two centuries, the biomedical paradigm is radically changed: from mechanistic to complex, holistic vision of human physiopathology and therapeutics. This emerging paradigm enables the best assessment of unconventional medical theories and complementary and alternative therapies; b) into the diversified unconventional medicines world an open-mind to scientific debate is rising, closing the ancient contrast to conventional medicine. The pathway is crucial, it could set out the scientific quality of the conventional, complementary and alternative medicine integration.