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, 44 (4), 1075-7

Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in Both Helicobacter Pylori and Mycobacterium Tuberculosis

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Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in Both Helicobacter Pylori and Mycobacterium Tuberculosis

M Heep et al. Antimicrob Agents Chemother.

Abstract

A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.

Figures

FIG. 1
FIG. 1
Alignment of the homologous amino acid sequences of the N-terminal region of RpoB of different species. The figure shows mapping of codons associated with the rifamycin resistance phenotype (boxes).

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