Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes

T Ono; S Shiota; K Hirota; K Nemoto; T Tsuchiya; Y Miyake

doi:10.1128/AAC.44.4.1078-1080.2000

Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes

Antimicrob Agents Chemother. 2000 Apr;44(4):1078-80. doi: 10.1128/AAC.44.4.1078-1080.2000.

Authors

T Ono¹, S Shiota, K Hirota, K Nemoto, T Tsuchiya, Y Miyake

Affiliation

¹ Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504, Japan. ono@dent.tokushima-u.ac.jp

Abstract

The susceptibility of viridans group streptococci to macrolides was determined. Thirteen isolates (17%) were resistant to erythromycin. Five strains carried an erm gene that was highly homologous to that in Tn917. Four strains had mefE genes that coded erythromycin efflux ability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Base Sequence
Carrier Proteins / genetics
DNA, Bacterial / drug effects
DNA, Bacterial / genetics
DNA-Binding Proteins / genetics
Drug Resistance, Microbial
Erythromycin / pharmacology*
Genes, Bacterial / genetics
Methyltransferases / genetics
Microbial Sensitivity Tests
Molecular Sequence Data
Mouth / microbiology*
Nasal Cavity / microbiology*
Reverse Transcriptase Polymerase Chain Reaction
Streptococcus / drug effects*
Streptococcus / genetics
Streptococcus oralis / drug effects*
Streptococcus oralis / genetics
Transcription Factors / genetics

Substances

Anti-Bacterial Agents
Carrier Proteins
DNA, Bacterial
DNA-Binding Proteins
Transcription Factors
Erythromycin
Methyltransferases
rRNA (adenosine-O-2'-)methyltransferase