A common polymorphism in the human insulin-like growth factor binding protein 3 gene

Mol Cell Probes. 2000 Feb;14(1):55-6. doi: 10.1006/mcpr.1999.0282.

Abstract

A common polymorphism generated by an A to C transition at nucleotide 7580 in the third intron of the insulin-like growth factor binding protein 3 gene was found. This polymorphism can be identified by Nde 1 restriction of genomic DNA amplified with a specifically designed restriction enzyme site-generating oligonucleotide primer. The frequency of the A and C alleles was estimated at 0.6 and 0.4 in the Caucasians, 0.63 and 0.37 in Blacks, respectively.

MeSH terms

  • African Continental Ancestry Group / genetics
  • Amino Acid Substitution
  • Chromosomes, Human, Pair 7
  • European Continental Ancestry Group / genetics
  • Gene Frequency
  • Genome
  • Heterozygote
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / genetics*
  • Introns
  • Molecular Sequence Data
  • Point Mutation
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Restriction Fragment Length

Substances

  • Insulin-Like Growth Factor Binding Protein 3

Associated data

  • GENBANK/J05537