Stem cell transplantation for treatment of severe autoimmune diseases: current status and future perspectives

Bone Marrow Transplant. 2000 Feb;25(4):351-6. doi: 10.1038/sj.bmt.1702152.


Autoimmune diseases include a heterogeneous group of disorders with variable presentation and severity. Immunosuppressive and immunomodulatory therapies are often used for treatment with considerable success in some cases. These diseases may also be severe and refractory to conventional treatment. Thus more aggressive intervention might be indicated in a subset of patients. Animal studies suggest that high-dose therapy supported by stem cell transplantation may lead to remissions in experimental autoimmune disease models. Anecdotal case reports suggest that the same may be the case in some human autoimmune diseases as well. This review attempts to summarise some current concepts and future perspectives on stem cell transplantation in the treatment of severe autoimmune diseases.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Autoimmune Diseases / therapy*
  • Forecasting
  • Hematopoietic Stem Cell Transplantation* / trends
  • Humans