Exposure, infection and immune responses to Schistosoma haematobium in young children

Parasitology. 2000 Jan;120 ( Pt 1):37-44. doi: 10.1017/s0031182099005156.

Abstract

Behavioural, parasitological and immunological data were obtained from 48 children up to 6 years old, resident in a Schistosoma haematobium endemic area in Zimbabwe. The children averaged more than 1 contact with infective water bodies every 3 days and all showed immunological evidence of exposure (an anti-cercarial and/or anti-egg antibody response). IgM was the dominant isotype and appeared in the youngest children, followed by IgA, IgE and IgG3. However, only 38 children showed evidence of infection (an anti-egg response or eggs in urine) and only 14 were excreting eggs. The best estimates from these data are that less than 1 in 100 contacts results in infection and less than 1 in 1000 result in egg output. This suggests that there may be substantial attrition of invading cercaria even in naïve individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use
  • Antibodies, Helminth / blood*
  • Antibodies, Monoclonal
  • Antigens, Helminth / blood
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Feces / parasitology
  • Humans
  • Immunoglobulins / blood
  • Infant
  • Likelihood Functions
  • Models, Biological
  • Parasite Egg Count
  • Praziquantel / therapeutic use
  • Prevalence
  • Schistosoma haematobium / immunology*
  • Schistosomiasis haematobia / blood
  • Schistosomiasis haematobia / epidemiology
  • Schistosomiasis haematobia / immunology*
  • Schistosomiasis haematobia / urine
  • Water / parasitology*
  • Zimbabwe / epidemiology

Substances

  • Anthelmintics
  • Antibodies, Helminth
  • Antibodies, Monoclonal
  • Antigens, Helminth
  • Immunoglobulins
  • Water
  • Praziquantel