Intralesional corticosteroid therapy in proliferating head and neck hemangiomas: a review of 155 cases

J Pediatr Surg. 2000 Mar;35(3):420-3. doi: 10.1016/s0022-3468(00)90205-7.


Purpose: The purpose of this paper is to review the effect of intralesional corticosteroid therapy in the treatment of 155 head and neck hemangiomas.

Methods: In the past 10 years, we have treated 155 proliferating head and neck hemangiomas with intralesional corticosteroid injections. Three to 6 injections of triamcinolone acetonide (10 mg/mL) in monthly intervals were given. Using slides and chart review, the results were assessed 1 month after completion of the treatment.

Results: Eighty-five percent of the lesions showed greater than 50% reduction in volume. Varied treatment response was noted in different classes of hemangioma. Eighty percent of the superficial, 75% of the deep, and 60% of the combined hemangiomas show more than 50% reduction in volume. Further growth was not found after treatment. The postinjection complication rate was 6.4% in this series. There were 2 patients with cushingoid appearance, 5 with cutaneous atrophy, and 3 suffered from anaphylactic shock. We found that lesions showing less than 50% reduction in volume were located mostly in the perioral area.

Conclusions: Intralesional corticosteroid injections are safe and effective in arresting hemangioma proliferation. Superficial hemangiomas yield the best results.

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use
  • Anaphylaxis / chemically induced
  • Child, Preschool
  • Head and Neck Neoplasms / drug therapy*
  • Hemangioma / drug therapy*
  • Humans
  • Infant
  • Injections, Intralesional
  • Treatment Outcome


  • Adrenal Cortex Hormones