A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana

Y H Kuo; C H Lin; S Y Hwang; Y C Shen; Y L Lee; L Shyh-Yuan

doi:10.1248/cpb.48.440

A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana

Chem Pharm Bull (Tokyo). 2000 Mar;48(3):440-1. doi: 10.1248/cpb.48.440.

Authors

Y H Kuo¹, C H Lin, S Y Hwang, Y C Shen, Y L Lee, L Shyh-Yuan

Affiliation

¹ National Research Institute of Chinese Medicine, and Chinese Culture University, Taipei, Taiwan, ROC.

PMID: 10726874
DOI: 10.1248/cpb.48.440

Abstract

Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Flavonoids / chemistry*
Flavonoids / isolation & purification
Flavonoids / pharmacology
Humans
Magnetic Resonance Spectroscopy
Plant Stems / chemistry
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Taiwan
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Flavonoids
taiwanhomoflavone A