A paradoxical rise of neonatal seizures after treatment with vitamin B6

Eur J Paediatr Neurol. 1998;2(6):319-22. doi: 10.1016/s1090-3798(98)80007-x.


We report the case of a newborn with intractable epileptic seizures developing a paradoxical rise of seizure frequency and electroencephalogram alterations after administration of vitamin B6. We have been unable to determine the aetiology of this disorder. In a newborn presenting with drug-resistant epileptic seizures, the first therapeutic option remains the application of intravenous pyridoxine, but the physician should be aware of the risk of an increase in seizure frequency.

Publication types

  • Case Reports

MeSH terms

  • Electroencephalography
  • Epilepsy / chemically induced*
  • Epilepsy / diagnosis
  • Humans
  • Infant, Newborn
  • Injections, Intravenous
  • Male
  • Periodicity
  • Pyridoxine / adverse effects*


  • Pyridoxine