The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis

Arthritis Rheum. 2000 Mar;43(3):515-21. doi: 10.1002/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T.


Objective: To investigate the possible association of mannose-binding lectin (MBL) genotypes with the outcome of rheumatoid arthritis (RA).

Methods: MBL genotypes and plasma concentrations were retrospectively determined in 140 RA patients who were selected from a major cohort followed up prospectively for up to 32 years.

Results: MBL-insufficient patients (those with 2 defective structural MBL alleles or with 1 defective allele combined with a low-expression variant of the normal allele) had unfavorable outcomes. The relative risk of a severe radiographic outcome event (30% of maximum radiographic destruction, or an RE30) was 3.1 (95% confidence interval 1.8-5.1) in the MBL-insufficient group versus the MBL-competent group (P < 0.0001). An RE30 occurred in 50% of MBL-competent patients within 17 years, while such an event occurred 9 years earlier in MBL-insufficient patients (i.e., within 8 years) (P < 0.0001). During the first 15 years, there was a significant trend toward lower hemoglobin levels (P < 0.04), higher erythrocyte sedimentation rates (P < 0.02), and a higher number of swollen joints (P < 0.05) in the MBL-insufficient group.

Conclusion: MBL genotypes giving rise to MBL insufficiency are highly significant risk factors for fast progression of radiographic joint destruction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Arthritis, Rheumatoid / diagnostic imaging*
  • Arthritis, Rheumatoid / genetics*
  • Carrier Proteins / blood
  • Carrier Proteins / genetics*
  • Collectins
  • Female
  • Genetic Variation
  • Genotype
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Retrospective Studies
  • Treatment Outcome


  • Carrier Proteins
  • Collectins