C. elegans vulval development as a model system to study the cancer biology of EGFR signaling

Cancer Metastasis Rev. 1999;18(2):203-13. doi: 10.1023/a:1006317206443.


Molecular genetic studies of C. elegans vulval development have helped to define an evolutionarily conserved signaling pathway from an EGF-like ligand through EGF-receptor, Ras and MAP kinase to the nucleus. Further studies have identified novel positive regulators such as KSR-1 and SUR-8/SOC-2 and negative regulators such as cbl/SLI-1. The many negative regulatory proteins might serve to prevent inappropriate signaling, and thus are analogous to tumor suppressor genes.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / genetics
  • ErbB Receptors / physiology*
  • Female
  • Models, Biological
  • Neoplasms, Experimental / metabolism*
  • Signal Transduction / physiology*
  • Vulva / embryology*


  • ErbB Receptors