Abstract
Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging
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Alphavirus Infections / immunology*
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Alphavirus Infections / mortality
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Alphavirus Infections / virology
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Animals
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Antibodies, Monoclonal / immunology
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Antibodies, Viral / immunology*
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Central Nervous System / virology
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Central Nervous System Viral Diseases / immunology
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Central Nervous System Viral Diseases / mortality
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Central Nervous System Viral Diseases / virology
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Interferon-alpha / deficiency
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Interferon-alpha / physiology*
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Interferon-beta / deficiency
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Interferon-beta / physiology*
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Mice
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Mice, Inbred C57BL
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Sindbis Virus / immunology*
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Sindbis Virus / physiology
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Viral Load
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Virus Replication
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Interferon-alpha
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Interferon-beta