A protective role for innate immunity in autoimmune disease

Clin Immunol. 2000 Apr;95(1 Pt 2):S30-8. doi: 10.1006/clim.1999.4813.


Systemic lupus erythematosus is an incurable autoimmune disease characterized by autoantibodies directed against highly conserved nuclear proteins and DNA. While the cause of lupus is not known, B-lymphocytes are essential for disease. Most striking is that deficiency in components of the innate immune system such as complement is a major risk factor in disease. One explanation for the involvement of complement and innate immunity is that they are important in the induction and maintenance of B cell tolerance to lupus antigens.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Female
  • Humans
  • Immunity, Innate / physiology*
  • Male