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. 2000 Mar 24;287(5461):2185-95.
doi: 10.1126/science.287.5461.2185.

The Genome Sequence of Drosophila Melanogaster

M D Adams  1 S E CelnikerR A HoltC A EvansJ D GocayneP G AmanatidesS E SchererP W LiR A HoskinsR F GalleR A GeorgeS E LewisS RichardsM AshburnerS N HendersonG G SuttonJ R WortmanM D YandellQ ZhangL X ChenR C BrandonY H RogersR G BlazejM ChampeB D PfeifferK H WanC DoyleE G BaxterG HeltC R NelsonG L GaborJ F AbrilA AgbayaniH J AnC Andrews-PfannkochD BaldwinR M BallewA BasuJ BaxendaleL BayraktarogluE M BeasleyK Y BeesonP V BenosB P BermanD BhandariS BolshakovD BorkovaM R BotchanJ BouckP BroksteinP BrottierK C BurtisD A BusamH ButlerE CadieuA CenterI ChandraJ M CherryS CawleyC DahlkeL B DavenportP DaviesB de PablosA DelcherZ DengA D MaysI DewS M DietzK DodsonL E DoupM DownesS Dugan-RochaB C DunkovP DunnK J DurbinC C EvangelistaC FerrazS FerrieraW FleischmannC FoslerA E GabrielianN S GargW M GelbartK GlasserA GlodekF GongJ H GorrellZ GuP GuanM HarrisN L HarrisD HarveyT J HeimanJ R HernandezJ HouckD HostinK A HoustonT J HowlandM H WeiC IbegwamM JalaliF KalushG H KarpenZ KeJ A KennisonK A KetchumB E KimmelC D KodiraC KraftS KravitzD KulpZ LaiP LaskoY LeiA A LevitskyJ LiZ LiY LiangX LinX LiuB MatteiT C McIntoshM P McLeodD McPhersonG MerkulovN V MilshinaC MobarryJ MorrisA MoshrefiS M MountM MoyB MurphyL MurphyD M MuznyD L NelsonD R NelsonK A NelsonK NixonD R NusskernJ M PaclebM PalazzoloG S PittmanS PanJ PollardV PuriM G ReeseK ReinertK RemingtonR D SaundersF ScheelerH ShenB C ShueI Sidén-KiamosM SimpsonM P SkupskiT SmithE SpierA C SpradlingM StapletonR StrongE SunR SvirskasC TectorR TurnerE VenterA H WangX WangZ Y WangD A WassarmanG M WeinstockJ WeissenbachS M WilliamsWoodageTK C WorleyD WuS YangQ A YaoJ YeR F YehJ S ZaveriM ZhanG ZhangQ ZhaoL ZhengX H ZhengF N ZhongW ZhongX ZhouS ZhuX ZhuH O SmithR A GibbsE W MyersG M RubinJ C Venter
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The Genome Sequence of Drosophila Melanogaster

M D Adams et al. Science. .

Abstract

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

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