Quinolones for short-term treatment of uncomplicated urinary tract infection

East Afr Med J. 1999 Oct;76(10):587-9.

Abstract

Objective: To investigate whether quinolones produce in vivo responses comparable to reported in vitro activity against the spectrum of organisms in uncomplicated urinary tract infection (UTI) in Nigeria.

Design: Equal numbers of patients with urine culture positive UTI were randomized to oral quinolone, perfloxacin 400 mg bd twice a day and ofloxacin 200 mg bd twice a day for five days.

Setting: Out-patient clinics and wards at the University College Hospital, Ibadan.

Subjects: Sixty patients aged sixteen years and above with uncomplicated UTI.

Main outcome measures: Number of isolates, number of patients with clinical and bacteriological cure one week after commencing therapy. Relative effectiveness and side effects of the drugs.

Results: Sixty- four bacterial isolates were obtained with the enterobacteriaceae comprising 86%. Sixty-two (97%) were sensitive to both drugs in vitro. Clinical cure occurred in 57 patients (95%), being 28 (93%) in those taking perfloxacin and 29 (97%) in those taking ofloxacin. Bacteriological cure occurred in 55 patients (92%), being 27 (90%) in those taking perfloxacin and 28 (93%) in those taking ofloxacin. Fifty-nine of the 64 isolates (92%) were eliminated in one week, 30 of 33 (91%) in those taking perfloxacin, and 29 of 31 (94%) in those taking ofloxacin; the difference was insignificant (p = 1.16). The enterobacteriaceae were generally susceptible to both drugs. Side effects were minor and infrequent.

Conclusion: Quinolones were highly active against the common urinary pathogens in these Nigerian patients and can be reliably employed in treatment when culture results are unavailable.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • 4-Quinolones*
  • Administration, Oral
  • Adult
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / therapeutic use*
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Bacterial Infections / urine
  • Female
  • Fluoroquinolones*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Nigeria
  • Ofloxacin / pharmacology
  • Ofloxacin / therapeutic use*
  • Single-Blind Method
  • Time Factors
  • Treatment Outcome
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / urine

Substances

  • 4-Quinolones
  • Anti-Infective Agents
  • Fluoroquinolones
  • perfloxacin
  • Ofloxacin