Bilateral sequential single lung transplantation for pulmonary hypertension and Eisenmenger's syndrome

Ann Thorac Surg. 2000 Feb;69(2):381-7. doi: 10.1016/s0003-4975(99)01082-6.


Background: Lung transplantation, with and without intracardiac repair for pulmonary hypertension (PH) and Eisenmenger's syndrome (EIS), has become an alternative transplant strategy to combined heart and lung transplantation (HLT).

Methods: Thirty-five patients with PH or EIS underwent either bilateral sequential single lung transplantation (BSSLT, group I, n = 13) or HLT (group II, n = 22). Another 74 patients, who underwent BSSLT for other indications, served as controls (group III). Immediate allograft function, early and medium-term outcomes, lung function, and 2-year survival were compared between the groups.

Results: Comparisons between groups I and II showed no significant difference in any variables except percent predicted forced vital capacity. Immediate allograft function was significantly inferior (p < 0.05) and the blood loss was greater (p < 0.01) in group I when compared with those in group III. However, this resulted in no significant difference in early and medium-term outcomes, and 2-year survival between the 2 groups.

Conclusions: BSSLT for PH and EIS can be performed as an alternative procedure to HLT without an increase in early and medium-term morbidity and mortality. Results are comparable with BSSLT performed for other indications.

MeSH terms

  • Adult
  • Eisenmenger Complex / physiopathology
  • Eisenmenger Complex / surgery*
  • Female
  • Hemodynamics
  • Humans
  • Hypertension, Pulmonary / physiopathology
  • Hypertension, Pulmonary / surgery*
  • Lung Transplantation* / methods
  • Lung Transplantation* / physiology
  • Male
  • Postoperative Period
  • Retrospective Studies
  • Treatment Outcome