Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates

J Bacteriol. 2000 Apr;182(8):2332-5. doi: 10.1128/JB.182.8.2332-2335.2000.

Abstract

Two new tprD alleles have been identified in Treponema pallidum: tprD2 is found in 7 of 12 T. pallidum subsp. pallidum isolates and 7 of 8 non-pallidum isolates, and tprD3 is found in one T. pallidum subsp. pertenue isolate. Antibodies against TprD2 are found in persons with syphilis, demonstrating that tprD2 is expressed during infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Antibodies, Bacterial / blood
  • Bacterial Outer Membrane Proteins / genetics*
  • Bacterial Outer Membrane Proteins / immunology
  • Gene Duplication
  • Genes, Bacterial*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Syphilis / blood
  • Treponema pallidum / genetics*
  • Treponema pallidum / immunology

Substances

  • Antibodies, Bacterial
  • Bacterial Outer Membrane Proteins
  • Tpr protein, Treponema