Immature B cells in bone marrow express Fas/FasL

Scand J Immunol. 2000 Mar;51(3):279-84. doi: 10.1046/j.1365-3083.2000.00701.x.

Abstract

Negative selection is a process by which autoreactive lymphocytes are eliminated from the developing antigen receptor repertoire. The mechanisms regulating negative selection of immature B lymphocytes in the bone marrow are poorly elucidated. Human bone marrow cells were examined in order to investigate the presence of the members of the Fas (APO-1/CD95) system. Here we demonstrate the expression of Fas in immature B lymphocytes (CD10/CD19+/CD40+/sIg+), and the presence of Fas natural ligand (FasL) in CD19+ bone marrow cells. The observed expression of apoptosis-related molecules might indicate how negative selection of autoreactive B cells can occur in human bone marrow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD19 / biosynthesis
  • Apoptosis / immunology
  • B-Lymphocyte Subsets / cytology
  • B-Lymphocyte Subsets / immunology*
  • B-Lymphocyte Subsets / metabolism*
  • B-Lymphocyte Subsets / pathology
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / immunology*
  • Bone Marrow Cells / metabolism*
  • Bone Marrow Cells / pathology
  • Cell Differentiation / immunology
  • Cell Line, Transformed
  • Fas Ligand Protein
  • Humans
  • Ligands
  • Membrane Glycoproteins / biosynthesis*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Receptors, Antigen, B-Cell / biosynthesis
  • Tumor Cells, Cultured
  • Up-Regulation / immunology
  • fas Receptor / biosynthesis*
  • fas Receptor / metabolism

Substances

  • Antigens, CD19
  • FASLG protein, human
  • Fas Ligand Protein
  • Ligands
  • Membrane Glycoproteins
  • Receptors, Antigen, B-Cell
  • fas Receptor